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Mouse Anti-PTPRF Recombinant Antibody (A1409) (CBMAB-AP11357LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A1409
Antibody Isotype
IgG2a
Application
ICC/IF, WB

Basic Information

Immunogen
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PTPRF
Entrez Gene ID
Human5792
Mouse19268
Rat360406
UniProt ID
HumanP10586
MouseA2A8L5
RatQ64604
Alternative Names
FLJ43335 Antibody, FLJ45062 Antibody, FLJ45567 Antibody, LAR Antibody, LAR protein Antibody, LARFN5C Antibody, LARS Antibody, LCA homolog Antibody, Leukocyte antigen related (LAR) PTP receptor Antibody, Leukocyte antigen related Antibody, Leukocyte antige
Function
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of receptor bindingManual Assertion Based On ExperimentIMP:UniProtKB
Neuron projection regenerationIEA:Ensembl
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon regenerationIEA:Ensembl
Synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO
Transmembrane receptor protein tyrosine phosphatase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Involvement in disease
Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2):
A group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia).
Topology
Extracellular: 30-1263
Helical: 1264-1284
Cytoplasmic: 1285-1907
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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