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Rabbit Anti-PTPRF Recombinant Antibody (E6W4X) (CBMAB-CP1351-LY)

The product is antibody recognizes PTPRF. The antibody E6W4X immunoassay techniques such as: WB,IP,IF (ICC).
See all PTPRF antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
E6W4X
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant protein from a central region of the human PTPRF/LAR protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PTPRF
Entrez Gene ID
5792
UniProt ID
P10586
Function
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of receptor bindingManual Assertion Based On ExperimentIMP:UniProtKB
Neuron projection regenerationIEA:Ensembl
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon regenerationIEA:Ensembl
Synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO
Transmembrane receptor protein tyrosine phosphatase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Involvement in disease
Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2):
A group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia).
Topology
Extracellular: 30-1263
Helical: 1264-1284
Cytoplasmic: 1285-1907
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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