Sign in or Register   Sign in or Register
  |  

Mouse Anti-TBL1Y Recombinant Antibody (CB11A) (CBMAB-CA011LY)

The product is antibody recognizes TBL1Y. The antibody CB11A immunoassay techniques such as: ELISA, WB, ICC.
See all TBL1Y antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Porcine, Rat, Canine
Clone
CB11A
Antibody Isotype
IgG2b
Application
ELISA, WB, ICC

Basic Information

Immunogen
Recombinant full length protein (522aa) of Human TBL1Y.
Specificity
Human, Mouse, Porcine, Rat, Canine
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TBL1Y Gene(Protein Coding) Transducin Beta Like 1 Y-Linked
Introduction
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Entrez Gene ID
90665
UniProt ID
Q9BQ87
Alternative Names
Transducin Beta Like 1 Y-Linked; Transducin-Beta-Like Protein 1, Y-Linked; Transducin Beta-Like Protein 1Y; TBL1; F-Box-Like/WD Repeat-Containing Protein TBL1Y; Transducin (Beta)-Like 1, Y-Linked; Transducin Beta Like 1, Y-Linked; Transducin Beta-Like 1;
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).
Biological Process
Biological Process histone deacetylationIBA:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Deafness, Y-linked 2 (DFNY2):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNY2 patients show bilateral symmetric hearing loss ranging from mild to severe, with onset in the third to fifth decades of life.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TBL1Y Recombinant Antibody (CB11A)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare