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ABCA7

ABCA7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN
Full Name
ATP Binding Cassette Subfamily A Member 7
Function
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylserine over phosphatidylcholine. Plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocyte differentiation. Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing. Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients.
Biological Process
Amyloid-beta clearance by cellular catabolic process
Amyloid-beta formation
Apolipoprotein A-I-mediated signaling pathway
Cholesterol efflux
High-density lipoprotein particle assembly
Lipid transport
Memory
Negative regulation of amyloid-beta formation
Negative regulation of amyloid precursor protein biosynthetic process
Negative regulation of endocytosis
Negative regulation of MAPK cascade
Negative regulation of PERK-mediated unfolded protein response
Peptide cross-linking
Phagocytosis
Phospholipid efflux
Phospholipid translocation
Plasma membrane raft organization
Positive regulation of amyloid-beta clearance
Positive regulation of cholesterol efflux
Positive regulation of engulfment of apoptotic cell
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of phagocytosis
Positive regulation of phospholipid efflux
Positive regulation of protein localization to cell surface
Protein localization to nucleus
Regulation of amyloid precursor protein catabolic process
Regulation of lipid metabolic process
Visual learning
Cellular Location
Cytoplasm; Early endosome membrane; Cell membrane; Golgi apparatus membrane; Phagocytic cup. Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney (By similarity).
Involvement in disease
A familial, late-onset form of Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death.
Topology
Helical: 22-42 aa
Extracellular: 43-549 aa
Helical: 550-1263 aa
Extracellular: 1264-1537 aa
Helical: 1538-1749 aa
PTM
N-glycosylated.

Anti-ABCA7 antibodies

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Target: ABCA7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-12489
Application*: WB, E, IF, P, IP
Target: ABCA7
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: V2-178919
Application*: WB, F, P
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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