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SHH

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]

Anti-SHH antibodies

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Mouse Anti-SHH Recombinant Antibody (1B11) (CBMAB-A8114-LY)

Target: SHH
Host: Mouse
Antibody Isotype: IgG2a, κ
Cross Reactivity: Human
Clone: 1B11
Application*: SE, E

Mouse Anti-SHH Recombinant Antibody (CBDH2738) (CBMAB-DH2738-LY)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Chicken, Human, Mouse, Quail, Rabbit, Rat
Clone: CBDH2738
Application*: FACS, Blocking, IF, IHC, WB

Rabbit Anti-SHH Recombinant Antibody (CBXS-6154) (CBMAB-S6334-CQ)

Target: SHH
Host: Rabbit
Antibody Isotype: IgG
Cross Reactivity: Chicken, Human, Mouse, Rat, African clawed frog, Zebrafish
Clone: CBXS-6154
Application*: WB

Rat Anti-SHH Recombinant Antibody (CBXS-1683) (CBMAB-S4525-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2a
Cross Reactivity: Mouse
Clone: CBXS-1683
Application*: ED

Rabbit Anti-SHH Recombinant Antibody (CBXS-3514) (CBMAB-S6243-CQ)

Target: SHH
Host: Rabbit
Antibody Isotype: IgG
Cross Reactivity: Human
Clone: CBXS-3514
Application*: F, IH, IP, WB

Rabbit Anti-SHH Recombinant Antibody (CBXS-3431) (CBMAB-S6162-CQ)

Target: SHH
Host: Rabbit
Antibody Isotype: IgG
Cross Reactivity: Human, Rat
Clone: CBXS-3431
Application*: WB

Rat Anti-SHH Recombinant Antibody (CBXS-2387) (CBMAB-S5145-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2a
Cross Reactivity: Human, Mouse
Clone: CBXS-2387
Application*: E, WB

Rat Anti-SHH Recombinant Antibody (CBXS-1857) (CBMAB-S4658-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2a
Cross Reactivity: Mouse
Clone: CBXS-1857
Application*: WB

Mouse Anti-SHH Recombinant Antibody (SH154) (CBMAB-S6560-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Mouse, Rat, Human
Clone: SH154
Application*: WB, E, DB

Mouse Anti-SHH Recombinant Antibody (CBXS-2441) (CBMAB-S5198-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Human, Monkey, Mouse
Clone: CBXS-2441
Application*: E, F, IH, WB

Mouse Anti-SHH Recombinant Antibody (CBXS-2440) (CBMAB-S5197-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Human
Clone: CBXS-2440
Application*: E, WB

Mouse Anti-SHH Recombinant Antibody (10H6) (CBMAB-S2799-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Human
Clone: 10H6
Application*: IF, WB

Rabbit Anti-SHH Recombinant Antibody (CBXS-6007) (CBMAB-S0853-CQ)

Target: SHH
Host: Rabbit
Antibody Isotype: IgG
Cross Reactivity: Human, Rat, Zebrafish, Mouse, Chicken, African clawed frog
Clone: CBXS-6007
Application*: WB

Rat Anti-SHH (C-Term) Recombinant Antibody (CBXS-2638) (CBMAB-S5392-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2a
Cross Reactivity: Mouse
Clone: CBXS-2638
Application*: N, WB

Rat Anti-SHH Recombinant Antibody (CBXS-2586) (CBMAB-S5342-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2
Cross Reactivity: Mouse
Clone: CBXS-2586
Application*: IH, N, WB

Rat Anti-SHH Recombinant Antibody (CBXS-2585) (CBMAB-S5341-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2
Cross Reactivity: Mouse
Clone: CBXS-2585
Application*: WB

Mouse Anti-SHH Recombinant Antibody (CBXS-2584) (CBMAB-S5340-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG2
Cross Reactivity: Human
Clone: CBXS-2584
Application*: WB

Rabbit Anti-SHH Recombinant Antibody (CBXS-1177) (CBMAB-S4047-CQ)

Target: SHH
Host: Rabbit
Antibody Isotype: IgG
Cross Reactivity: Human
Clone: CBXS-1177
Application*: WB, P, F, IF

Rat Anti-SHH Recombinant Antibody (CBXS-1682) (CBMAB-S4524-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2a
Cross Reactivity: Mouse
Clone: CBXS-1682
Application*: WB, IH, N, EC

Rat Anti-SHH Recombinant Antibody (CBXS-1681) (CBMAB-S4523-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2a
Cross Reactivity: Human, Mouse
Clone: CBXS-1681
Application*: WB

Mouse Anti-SHH Recombinant Antibody (CBXS-5287) (CBMAB-S2501-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Human
Clone: CBXS-5287
Application*: WB

Rat Anti-SHH Recombinant Antibody (CBXS-5665) (CBMAB-S0537-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2
Cross Reactivity: Mouse
Clone: CBXS-5665
Application*: WB

Mouse Anti-SHH Recombinant Antibody (5E1) (CBMAB-0252-CN)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Chicken, Human, Mouse, Quail, Rabbit, Rat
Clone: 5E1
Application*: F, B, IF, IH, WB

Mouse Anti-SHH Recombinant Antibody (CBXS-1137) (CBMAB-S4021-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Human
Clone: CBXS-1137
Application*: E

Rat Anti-SHH Recombinant Antibody (CBXS-5240) (CBMAB-S2455-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2
Cross Reactivity: Mouse
Clone: CBXS-5240
Application*: IH, N, WB

Mouse Anti-SHH Recombinant Antibody (CBXS-5196) (CBMAB-S2413-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Human, Mouse, Non-human primate
Clone: CBXS-5196
Application*: F, IH, WB

Rabbit Anti-SHH Recombinant Antibody (CBXS-4280) (CBMAB-S1528-CQ)

Target: SHH
Host: Rabbit
Antibody Isotype: IgG
Cross Reactivity: Human
Clone: CBXS-4280
Application*: F, IC, IF, WB

Mouse Anti-SHH Recombinant Antibody (CBFYH-2758) (CBMAB-H3821-FY)

Target: SHH
Host: Mouse
Cross Reactivity: Human
Clone: CBFYH-2758
Application*: WB, IC, P, C, E

Mouse Anti-SHH Recombinant Antibody (67.8) (CBMAB-S2879-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG1
Cross Reactivity: Human, Rat
Clone: 67.8
Application*: IF, WB

Mouse Anti-SHH Recombinant Antibody (CBXS-4732) (CBMAB-S1961-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG2a
Cross Reactivity: Human
Clone: CBXS-4732
Application*: IF, WB

Rat Anti-SHH Recombinant Antibody (CBXS-4619) (CBMAB-S1859-CQ)

Target: SHH
Host: Rat
Antibody Isotype: IgG2
Cross Reactivity: Human
Clone: CBXS-4619
Application*: WB

Mouse Anti-SHH Recombinant Antibody (CBXS-3859) (CBMAB-S1129-CQ)

Target: SHH
Host: Mouse
Antibody Isotype: IgG2a, κ
Cross Reactivity: Human
Clone: CBXS-3859
Application*: E
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)