A4GNT
This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]
Full Name
Alpha-1,4-N-Acetylglucosaminyltransferase
Function
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct. May protect against inflammation-associated gastric adenocarcinomas (By similarity).
Biological Process
Carbohydrate metabolic process
Glycoprotein biosynthetic process
Negative regulation of epithelial cell proliferation
O-glycan processing
Protein O-linked glycosylation
Glycoprotein biosynthetic process
Negative regulation of epithelial cell proliferation
O-glycan processing
Protein O-linked glycosylation
Cellular Location
Golgi apparatus membrane; Membrane protein
Topology
Cytoplasmic: 1-4 aa
Helical: 5-25 aa
Lumenal: 26-340 aa
Helical: 5-25 aa
Lumenal: 26-340 aa
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Anti-A4GNT antibodies
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Target: A4GNT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-178846
Application*: WB
Target: A4GNT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178845
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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