AADAC

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq]

Full Name

arylacetamide deacetylase (esterase)

Function

Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.

Biological Process

Positive regulation of triglyceride catabolic process
Xenobiotic metabolic process

Cellular Location

Endoplasmic reticulum membrane; Microsome membrane

Topology

Cytoplasmic: 1-5 aa
Helical: 6-23 aa
Lumenal: 24-399 aa

PTM

Glycosylation is required for enzyme activity.