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ADH5

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Full Name
Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide
Function
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol.
Biological Process
Ethanol oxidation
Fatty acid omega-oxidation
Formaldehyde catabolic process
Peptidyl-cysteine S-nitrosylation
Positive regulation of blood pressure
Respiratory system process
Response to lipopolysaccharide
Response to nitrosative stress
Response to redox state
Retinoid metabolic process
Cellular Location
Cytoplasm
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Anti-ADH5 antibodies

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Mouse Anti-ADH5 Recombinant Antibody (V2-633546) (CBMAB-FT295LY)

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Target: ADH5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-633546
Application*: ELISA, WB, IP
Datasheet SDS

Mouse Anti-ADH5 Recombinant Antibody (V2-179907) (CBMAB-A1291-YC)

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Target: ADH5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179907
Application*: WB, IH
Datasheet SDS

Mouse Anti-ADH5 Recombinant Antibody (V2-179905) (CBMAB-A1289-YC)

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Target: ADH5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179905
Application*: WB
Datasheet SDS

Mouse Anti-ADH5 Recombinant Antibody (V2-179904) (CBMAB-A1288-YC)

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Target: ADH5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179904
Application*: WB
Datasheet SDS

Mouse Anti-ADH5 Recombinant Antibody (V2-179903) (CBMAB-A1287-YC)

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Target: ADH5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179903
Application*: IH
Datasheet SDS

Mouse Anti-ADH5 Recombinant Antibody (V2-179902) (CBMAB-A1286-YC)

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Target: ADH5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-179902
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-ADH5 Recombinant Antibody (V2-66965) (CBMAB-G1249-LY)

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Target: ADH5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-66965
Application*: WB, IP, IF, E
Datasheet SDS

ADH5 Matched Antibody Pair (027) (APMAB-027LY)

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Target: ADH5
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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