Mouse Anti-ADH5 Recombinant Antibody (V2-179904) (CBMAB-A1288-YC)

Name: Mouse Anti-ADH5 Recombinant Antibody (V2-179904)
SKU: CBMAB-A1288-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179904

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-266 of human ADH5 (NP_000662) produced in E. coli

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Buffer

PBS, pH7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide

Introduction

ADH5 is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homod

Entrez Gene ID

128

UniProt ID

P11766

Alternative Names

Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide; Glutathione-Dependent Formaldehyde Dehydrogenase; S-(Hydroxymethyl)Glutathione Dehydrogenase; Alcohol Dehydrogenase Class Chi Chain; Alcohol Dehydrogenase Class-III; S-Nitrosoglutathione Reductase; For

Function

Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol.

Biological Process

Ethanol oxidation
Fatty acid omega-oxidation
Formaldehyde catabolic process
Peptidyl-cysteine S-nitrosylation
Positive regulation of blood pressure
Respiratory system process
Response to lipopolysaccharide
Response to nitrosative stress
Response to redox state
Retinoid metabolic process

Cellular Location

Cytoplasm

Zhao, J., Wei, Q., Gu, X. R., Ren, S. W., & Liu, X. N. (2020). Alcohol dehydrogenase 5 of Helicoverpa armigera interacts with the CYP6B6 promoter in response to 2‐tridecanone. Insect science, 27(5), 1053-1066.

Oka, Y., Hamada, M., Nakazawa, Y., Muramatsu, H., Okuno, Y., Higasa, K., ... & Ogi, T. (2020). Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome. Science Advances, 6(51), eabd7197.

Suo, C., Yang, Y., Yuan, Z., Zhang, T., Yang, X., Qing, T., ... & Ye, W. (2019). Alcohol intake interacts with functional genetic polymorphisms of aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) to increase esophageal squamous cell cancer risk. Journal of Thoracic Oncology, 14(4), 712-725.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

ADH5 Matched Antibody Pair (027) (CAT#: APMAB-027LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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