AGPAT5
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
Full Name
1-Acylglycerol-3-Phosphate O-Acyltransferase 5
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.
Biological Process
Acylglycerol metabolic process
CDP-diacylglycerol biosynthetic process
Hematopoietic progenitor cell differentiation
Phosphatidic acid biosynthetic process
Phospholipid biosynthetic process
CDP-diacylglycerol biosynthetic process
Hematopoietic progenitor cell differentiation
Phosphatidic acid biosynthetic process
Phospholipid biosynthetic process
Cellular Location
Endoplasmic reticulum membrane; Nucleus envelope; Mitochondrion
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Anti-AGPAT5 antibodies
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Target: AGPAT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180187
Application*: WB
Target: AGPAT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180186
Application*: IF, P, WB
Target: AGPAT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180185
Application*: P, WB
Target: AGPAT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180184
Application*: IH, WB
Target: AGPAT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180183
Application*: F, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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