ANGPTL7
ANGPTL7 (Angiopoietin Like 7) is a Protein Coding gene. An important paralog of this gene is ANGPT4.
Full Name
Angiopoietin Like 7
Function
Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036).
Biological Process
Angiogenesis Source: GO_Central
Negative regulation of vasculature development involved in avascular cornea development in camera-type eye Source: UniProtKB
Regulation of extracellular matrix organization Source: UniProtKB
Response to oxidative stress Source: ProtInc
Negative regulation of vasculature development involved in avascular cornea development in camera-type eye Source: UniProtKB
Regulation of extracellular matrix organization Source: UniProtKB
Response to oxidative stress Source: ProtInc
Cellular Location
Secreted
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Anti-ANGPTL7 antibodies
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Target: ANGPTL7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: Kairos 108-4
Application*: E, IH, WB
Target: ANGPTL7
Sensitivity: 0.046 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Angptl7
Sensitivity: 0.00095 ng/mL
Detection Range: 0.002-0.7 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: ANGPTL7
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: His Tag
Target: ANGPTL7
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: His Tag
Target: ANGPTL7
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-344
Tag: hFc Tag
Target: ANGPTL7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F1
Application*: SE, E, IF, WB
Target: ANGPTL7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E7
Application*: WB, E, IH
Target: ANGPTL7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2C7
Application*: WB, E
Target: ANGPTL7
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYC-A601
Application*: IH, WB
Target: ANGPTL7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: Kairos 397-7
Application*: E, WB
Target: ANGPTL7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2C6
Application*: E, IF, WB
Target: ANGPTL7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-181082
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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