AOC3

This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Full Name
Amine Oxidase, Copper Containing 3
Function
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Biological Process
Amine metabolic process Source: UniProtKB
Cell adhesion Source: UniProtKB
Inflammatory response Source: UniProtKB
Negative regulation of primary amine oxidase activity Source: UniProtKB
Response to antibiotic Source: UniProtKB
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-5 aa
Helical: 6-26 aa
Extracellular: 27-763 aa
PTM
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
N- and O-glycosylated.
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Anti-AOC3 antibodies

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Mouse Anti-AOC3 Recombinant Antibody (CBYY-0014) (CBMAB-0014-YY)

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Target: AOC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-0014
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-AOC3 Recombinant Antibody (CBYC-A641) (CBMAB-A2954-YC)

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Target: AOC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-A641
Application*: WB, IF, FC
Datasheet SDS

Mouse Anti-AOC3 Recombinant Antibody (4B8) (CBMAB-A2953-YC)

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Target: AOC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B8
Application*: E, IF
Datasheet SDS

Mouse Anti-AOC3 Recombinant Antibody (CBYY-1533) (CBMAB-1603-YY)

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Target: AOC3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-1533
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-AOC3 Recombinant Antibody (CBYY-0024) (CBMAB-0024-YY)

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Target: AOC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-0024
Application*: WB, IP, IF, E, P
Datasheet SDS

Human AOC3 ELISA Kit (V2LY-0626-LY5707)

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Target: AOC3
Sensitivity: 0.006 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Aoc3 ELISA Kit (V2LY-0626-LY2631)

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Target: Aoc3
Sensitivity: 0.228 ng/mL
Detection Range: 0.5-150 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Rat Aoc3 ELISA Kit (V2LY-0626-LY2427)

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Target: Aoc3
Sensitivity: 1.62 ng/mL
Detection Range: 3-900 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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