ARMCX3

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Full Name

Armadillo Repeat Containing, X-Linked 3

Function

Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.

Biological Process

Axonal transport of mitochondrion Source: Ensembl
Cellular protein localization Source: GO_Central
Mitochondrion organization Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl

Cellular Location

Cytoplasm; Nucleus; Mitochondrion outer membrane

Topology

Mitochondrial intermembrane: 1-6 aa
Helical: 7-29 aa
Cytoplasmic: 30-379 aa