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Mouse Anti-ARMCX3 Recombinant Antibody (EG251) (CBMAB-EN278-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
EG251
Antibody Isotype
IgG2a, κ
Application
WB, IP, ELISA

Basic Information

Immunogen
Recombinant ARMCX3 of human origin.
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Armadillo Repeat Containing, X-Linked 3
Introduction
This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human51566
Mouse71703
Rat367902
UniProt ID
HumanQ9UH62
MouseQ8BHS6
RatQ5XID7
Alternative Names
Armadillo Repeat Containing, X-Linked 3; ARM Protein Lost In Epithelial Cancers On Chromosome X 3; ALEX3; Arm Protein Lost In Epithelial Cancers, X Chromosome, 3; Armadillo Repeat-Containing X-Linked Protein 3; 1200004E24Rik; Protein ALEX3; DJ545K15.2; GASP6;
Function
Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.
Biological Process
Axonal transport of mitochondrion Source: Ensembl
Cellular protein localization Source: GO_Central
Mitochondrion organization Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; Mitochondrion outer membrane
Topology
Mitochondrial intermembrane: 1-6 aa
Helical: 7-29 aa
Cytoplasmic: 30-379 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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