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Mouse Anti-ARMCX3 Recombinant Antibody (CBYC-A787) (CBMAB-A3627-YC)


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Published Data
Mouse Anti-ARMCX3 Recombinant Antibody (CBYC-A787) CBMAB-A3627-YC in IHC
The expression of Alex3 in lung cancer specimens. (a) Alex3 revealed strong cytosolic expression in normal bronchial epithelium cells; however, Alex3 showed negative or dim expression in (b) squamous cell carcinoma and (c) adenocarcinoma (magnification: 200×). (d) Alex was highly expressed in non-cancerous tissues than lung carcinoma (magnification: 200×). (e)Kaplan-Meier analysis results indicated that the overall survival of patients with positive Alex3 expression was significantly longer than those without. ...View More
Du, J., Zhang, X., Zhou, H., Miao, Y., Han, Y., Han, Q., & Wang, E. (2017). Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway. Tumor Biology, 39(7), 1010428317701441.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Pig
Clone
CBYC-A787
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 98-129 within an internal region of ARMCX3 of human origin.
Specificity
Human, Mouse, Rat, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Armadillo Repeat Containing, X-Linked 3
Introduction
ARMCX3 is a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involv
Entrez Gene ID
51566
UniProt ID
Q9UH62
Alternative Names
Armadillo Repeat Containing, X-Linked 3; ARM Protein Lost In Epithelial Cancers On Chromosome X 3; ALEX3; Arm Protein Lost In Epithelial Cancers, X Chromosome, 3; Armadillo Repeat-Containing X-Linked Protein 3; 1200004E24Rik; Protein ALEX3; DJ545K15.2; GA
Function
Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.
Biological Process
Axonal transport of mitochondrion Source: Ensembl
Cellular protein localization Source: GO_Central
Mitochondrion organization Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; Mitochondrion outer membrane
Topology
Mitochondrial intermembrane: 1-6 aa
Helical: 7-29 aa
Cytoplasmic: 30-379 aa
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For research use only. Not intended for any clinical use.

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