ATP10A

ATP10A belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to ano

Full Name

ATPase Phospholipid Transporting 10A (Putative)

Function

Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492).
Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178).
Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:29599178, PubMed:25947375).
Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492).

Biological Process

Ion transmembrane transport Source: Reactome
Phospholipid translocation Source: GO_Central
Positive regulation of membrane tubulation Source: UniProtKB
Regulation of cell shape Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane; Cell membrane. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.

Topology

Cytoplasmic: 1-86 aa
Helical: 87-106 aa
Exoplasmic loop: 107-110 aa
Helical: 111-128 aa
Cytoplasmic: 129-309 aa
Helical: 310-332 aa
Exoplasmic loop: 333-362 aa
Helical: 363-384 aa
Cytoplasmic: 385-1087 aa
Helical: 1088-1108 aa
Exoplasmic loop: 1109-1119 aa
Helical: 1120-1140 aa
Cytoplasmic: 1141-1170 aa
Helical: 1171-1192 aa
Exoplasmic loop: 1193-1199 aa
Helical: 1200-1222 aa
Cytoplasmic: 1223-1228 aa
Helical: 1229-1249 aa
Exoplasmic loop: 1250-1267 aa
Helical: 1268-1292 aa
Cytoplasmic: 1293-1499 aa

PTM

Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.