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ATP10A

ATP10A belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to ano
Full Name
ATPase Phospholipid Transporting 10A (Putative)
Function
Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492).
Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178).
Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:29599178, PubMed:25947375).
Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492).
Biological Process
Ion transmembrane transport Source: Reactome
Phospholipid translocation Source: GO_Central
Positive regulation of membrane tubulation Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane; Cell membrane. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
Topology
Cytoplasmic: 1-86 aa
Helical: 87-106 aa
Exoplasmic loop: 107-110 aa
Helical: 111-128 aa
Cytoplasmic: 129-309 aa
Helical: 310-332 aa
Exoplasmic loop: 333-362 aa
Helical: 363-384 aa
Cytoplasmic: 385-1087 aa
Helical: 1088-1108 aa
Exoplasmic loop: 1109-1119 aa
Helical: 1120-1140 aa
Cytoplasmic: 1141-1170 aa
Helical: 1171-1192 aa
Exoplasmic loop: 1193-1199 aa
Helical: 1200-1222 aa
Cytoplasmic: 1223-1228 aa
Helical: 1229-1249 aa
Exoplasmic loop: 1250-1267 aa
Helical: 1268-1292 aa
Cytoplasmic: 1293-1499 aa
PTM
Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.

Anti-ATP10A antibodies

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Target: ATP10A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: G-9
Application*: WB, IP, IF, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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