ATP11B

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM

Full Name

ATPase, class VI, type 11B

Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401).
May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401).

Biological Process

Aminophospholipid transport Source: UniProtKB
Ion transmembrane transport Source: Reactome
Ion transport Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phospholipid translocation Source: GO_Central

Cellular Location

Recycling endosome membrane; Early endosome; Trans-Golgi network; Endoplasmic reticulum. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794).

Topology

Cytoplasmic: 1-55 aa
Helical: 56-77 aa
Extracellular: 78-82 aa
Helical: 83-104 aa
Cytoplasmic: 105-289 aa
Helical: 290-311 aa
Extracellular: 312-341 aa
Helical: 342-359 aa
Cytoplasmic: 360-876 aa
Helical: 877-898 aa
Extracellular: 899-910 aa
Helical: 911-930 aa
Cytoplasmic: 931-960 aa
Helical: 961-982 aa
Extracellular: 983-997 aa
Helical: 998-1020 aa
Cytoplasmic: 1021-1025 aa
Helical: 1026-1047 aa
Extracellular: 1048-1065 aa
Helical: 1066-1090 aa
Cytoplasmic: 1091-1177 aa