Mouse Anti-ATP11B Recombinant Antibody (CBYC-A871) (CBMAB-A4001-YC)

Name: Mouse Anti-ATP11B Recombinant Antibody (CBYC-A871)
SKU: CBMAB-A4001-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-A871

Application

ELISA, WB

Immunogen

ATP11B (NP_055431, 1087 a.a. ~ 1177 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ATPase, class VI, type 11B

Introduction

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified.

Entrez Gene ID

23200

UniProt ID

Q9Y2G3

Alternative Names

ATPase Phospholipid Transporting 11B (Putative); P4-ATPase Flippase Complex Alpha Subunit ATP11B; ATPase, Class VI, Type 11B; EC 3.6.3.1; ATPase IR; ATPIF; ATPIR;

Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401).
May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401).

Biological Process

Aminophospholipid transport Source: UniProtKB
Ion transmembrane transport Source: Reactome
Ion transport Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phospholipid translocation Source: GO_Central

Cellular Location

Recycling endosome membrane; Early endosome; Trans-Golgi network; Endoplasmic reticulum. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794).

Topology

Cytoplasmic: 1-55 aa
Helical: 56-77 aa
Extracellular: 78-82 aa
Helical: 83-104 aa
Cytoplasmic: 105-289 aa
Helical: 290-311 aa
Extracellular: 312-341 aa
Helical: 342-359 aa
Cytoplasmic: 360-876 aa
Helical: 877-898 aa
Extracellular: 899-910 aa
Helical: 911-930 aa
Cytoplasmic: 931-960 aa
Helical: 961-982 aa
Extracellular: 983-997 aa
Helical: 998-1020 aa
Cytoplasmic: 1021-1025 aa
Helical: 1026-1047 aa
Extracellular: 1048-1065 aa
Helical: 1066-1090 aa
Cytoplasmic: 1091-1177 aa

Hawkey-Noble, A., Umali, J., Fowler, G., & French, C. R. (2020). Expression of three P4-phospholipid flippases—atp11a, atp11b, and atp11c in zebrafish (Danio rerio). Gene Expression Patterns, 36, 119115.

Wang, J., Li, W., Zhou, F., Feng, R., Wang, F., Zhang, S., ... & Wen, T. (2019). ATP11B deficiency leads to impairment of hippocampal synaptic plasticity. Journal of molecular cell biology, 11(8), 688-702.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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