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Mouse Anti-ATP11B Recombinant Antibody (CBYC-A871) (CBMAB-A4001-YC)

Provided herein is a Mouse monoclonal antibody against Human ATPase Phospholipid Transporting 11B (Putative). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ATP11B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-A871
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
ATP11B (NP_055431, 1087 a.a. ~ 1177 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase, class VI, type 11B
Introduction
P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified.
Entrez Gene ID
23200
UniProt ID
Q9Y2G3
Alternative Names
ATPase Phospholipid Transporting 11B (Putative); P4-ATPase Flippase Complex Alpha Subunit ATP11B; ATPase, Class VI, Type 11B; EC 3.6.3.1; ATPase IR; ATPIF; ATPIR;
Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401).
May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401).
Biological Process
Aminophospholipid transport Source: UniProtKB
Ion transmembrane transport Source: Reactome
Ion transport Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phospholipid translocation Source: GO_Central
Cellular Location
Recycling endosome membrane; Early endosome; Trans-Golgi network; Endoplasmic reticulum. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794).
Topology
Cytoplasmic: 1-55 aa
Helical: 56-77 aa
Extracellular: 78-82 aa
Helical: 83-104 aa
Cytoplasmic: 105-289 aa
Helical: 290-311 aa
Extracellular: 312-341 aa
Helical: 342-359 aa
Cytoplasmic: 360-876 aa
Helical: 877-898 aa
Extracellular: 899-910 aa
Helical: 911-930 aa
Cytoplasmic: 931-960 aa
Helical: 961-982 aa
Extracellular: 983-997 aa
Helical: 998-1020 aa
Cytoplasmic: 1021-1025 aa
Helical: 1026-1047 aa
Extracellular: 1048-1065 aa
Helical: 1066-1090 aa
Cytoplasmic: 1091-1177 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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