Bcl3

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.

Full Name

B Cell CLL/Lymphoma 3

Function

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).

Biological Process

Antimicrobial humoral response Source: Ensembl
Cellular response to DNA damage stimulus Source: UniProtKB
Defense response to bacterium Source: Ensembl
Defense response to protozoan Source: Ensembl
DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
Extracellular matrix organization Source: Ensembl
Follicular dendritic cell differentiation Source: Ensembl
Germinal center formation Source: Ensembl
Humoral immune response mediated by circulating immunoglobulin Source: Ensembl
I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
Maintenance of protein location in nucleus Source: UniProtKB
Marginal zone B cell differentiation Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of interleukin-8 production Source: UniProtKB
Negative regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: Ensembl
Positive regulation of interferon-gamma production Source: Ensembl
Positive regulation of interleukin-10 production Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of translation Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of DNA binding Source: UniProtKB
Regulation of NIK/NF-kappaB signaling Source: UniProtKB
Response to UV-C Source: UniProtKB
Response to virus Source: UniProtKB
Spleen development Source: Ensembl
T-helper 1 type immune response Source: Ensembl
T-helper 2 cell differentiation Source: Ensembl
Transcription, DNA-templated Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus; Perinuclear region. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.

PTM

Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).
Activated by phosphorylation.