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Hamster Anti-BCL3 Recombinant Antibody (CBYY-0431) (CBMAB-0433-YY)

This product is hamster antibody that recognizes BCL3. The antibody CBYY-0431 can be used for immunoassay techniques such as: ELISA, WB
See all BCL3 antibodies
Published Data
Hamster Anti-BCL3 Recombinant Antibody (CBYY-0431) (CBMAB-0433-YY) in WB
Expression of IκB proteins in ovine liver. Note: DN16 = day 16 of the oestrous cycle; DP13 = day 13 of pregnancy; DP16 = day 16 of pregnancy; DP25 = day 25 of pregnancy. Significant differences (p < 0.05) are indicated by different superscript letters within the same colour column. ...View More
Cai, C., Ren, Y., Cao, J., Fang, S., Zhang, L., & Yang, L. (2023). Expression of IkappaB Family in the Ovine Liver during Early Pregnancy. Animals, 13(6), 1057.
Hamster Anti-BCL3 Recombinant Antibody (CBYY-0431) (CBMAB-0433-YY) in WB
Expression of IκB family proteins in ovine spleen analyzed by Western blotting. Note: DN16 = day 16 of the estrous cycle; DP13 = day 13 of pregnancy; DP16 = day 16 of pregnancy; DP25 = day 25 of pregnancy. Expression of IκB family proteins in ovine spleen analyzed by Western blotting. Note: DN16 = day 16 of the estrous cycle; DP13 = day 13 of pregnancy; DP16 = day 16 of pregnancy; DP25 = day 25 of pregnancy. Significant differences (p < 0.05) are indicated by different superscript letters within the same color column. p values between 0.001 and 0.01 are shown with two (**) asterisks, and p value less than 0.001 is designated with three (***) asterisks. ...View More
Fang, S., Cai, C., Bai, Y., Zhang, L., & Yang, L. (2023). Early Pregnancy Regulates Expression of IkappaB Family in Ovine Spleen and Lymph Nodes. International Journal of Molecular Sciences, 24(6), 5156.
Hamster Anti-BCL3 Recombinant Antibody (CBYY-0431) (CBMAB-0433-YY) in WB
PKCβ siRNA reduces the level of Bcl3. HeLa cells were transfected overnight with scrambled (Co) or PKCβ siRNA. Subsequently, cells were stimulated with 80 ng/mL TNF up to 6 h and Bcl3 was determined in whole cell extracts (n=3, representative experiment). ...View More
Welz, B., Bikker, R., Hoffmeister, L., Diekmann, M., Christmann, M., Brand, K., & Huber, R. (2021). Activation of GSK3 Prevents Termination of TNF-Induced Signaling. Journal of Inflammation Research, 14, 1717.
Hamster Anti-BCL3 Recombinant Antibody (CBYY-0431) (CBMAB-0433-YY) in WB
Hep3B cells were transfected with miR-627-5p mimics or scrambled control and detected by western blot for BCL3 expression. n = three independent repeats. ...View More
Wang, J., Chen, T., Wang, L., Yao, B., Sun, L., Chen, S., & Liu, Q. (2020). MicroRNA-627-5p inhibits the proliferation of hepatocellular carcinoma cells by targeting BCL3 transcription coactivator. Clinical and Experimental Pharmacology and Physiology, 47(3), 485-494.
Hamster Anti-BCL3 Recombinant Antibody (CBYY-0431) (CBMAB-0433-YY) in WB
BCL3 expression was restored by transfecting expression plasmid in miR-627-5p overexpressing Hep3B cells and western blot was carried out to detect BCL3 expression. ...View More
Wang, J., Chen, T., Wang, L., Yao, B., Sun, L., Chen, S., & Liu, Q. (2020). MicroRNA-627-5p inhibits the proliferation of hepatocellular carcinoma cells by targeting BCL3 transcription coactivator. Clinical and Experimental Pharmacology and Physiology, 47(3), 485-494.

Summary

Host Animal
Hamster
Specificity
Human, Mouse, Rat
Clone
CBYY-0431
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Full length Bcl-3 of mouse origin.
Host Species
Hamster
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
B Cell CLL/Lymphoma 3
Introduction
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forMouse a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
Entrez Gene ID
Human602
Mouse12051
UniProt ID
HumanP20749
MouseQ9Z2F6
Alternative Names
B Cell CLL/Lymphoma 3; Chronic Lymphatic Leukemia Protein; B-Cell Lymphoma 3-Encoded Protein; B-Cell Leukemia/Lymphoma 3; Proto-Oncogene BCL3; D19S37;
Function
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
Biological Process
Antimicrobial humoral response Source: Ensembl
Cellular response to DNA damage stimulus Source: UniProtKB
Defense response to bacterium Source: Ensembl
Defense response to protozoan Source: Ensembl
DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
Extracellular matrix organization Source: Ensembl
Follicular dendritic cell differentiation Source: Ensembl
Germinal center formation Source: Ensembl
Humoral immune response mediated by circulating immunoglobulin Source: Ensembl
I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
Maintenance of protein location in nucleus Source: UniProtKB
Marginal zone B cell differentiation Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of interleukin-8 production Source: UniProtKB
Negative regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: Ensembl
Positive regulation of interferon-gamma production Source: Ensembl
Positive regulation of interleukin-10 production Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of translation Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of DNA binding Source: UniProtKB
Regulation of NIK/NF-kappaB signaling Source: UniProtKB
Response to UV-C Source: UniProtKB
Response to virus Source: UniProtKB
Spleen development Source: Ensembl
T-helper 1 type immune response Source: Ensembl
T-helper 2 cell differentiation Source: Ensembl
Transcription, DNA-templated Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus; Perinuclear region. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
PTM
Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).
Activated by phosphorylation.

Prasongsukarn, K., Dechkhajorn, W., Benjathummarak, S., & Maneerat, Y. (2021). TRPM2, PDLIM5, BCL3, CD14, GBA genes as feasible markers for premature coronary heart disease risk. Frontiers in Genetics, 12.

Soukupová, J., Bordoni, C., Turnham, D. J., Yang, W. W., Seaton, G., Gruca, A., ... & Brancale, A. (2021). The Discovery of a Novel Antimetastatic Bcl3 Inhibitor. Molecular Cancer Therapeutics, 20(5), 775-786.

Wang, J., Chen, T., Wang, L., Yao, B., Sun, L., Chen, S., & Liu, Q. (2020). MicroRNA‐627‐5p inhibits the proliferation of hepatocellular carcinoma cells by targeting BCL3 transcription coactivator. Clinical and Experimental Pharmacology and Physiology, 47(3), 485-494.

Kang, S., Yun, J., Da Yeon Kim, S. Y. J., Kim, Y. J., Park, J. H., Ji, S. T., ... & Kwon, S. M. (2018). Adequate concentration of B cell leukemia/lymphoma 3 (Bcl3) is required for pluripotency and self-renewal of mouse embryonic stem cells via downregulation of Nanog transcription. BMB reports, 51(2), 92.

Wu, L., Bernal, G. M., Cahill, K. E., Pytel, P., Fitzpatrick, C. A., Mashek, H., ... & Yamini, B. (2018). BCL3 expression promotes resistance to alkylating chemotherapy in gliomas. Science translational medicine, 10(448).

Zou, Y., Uddin, M. M., Padmanabhan, S., Zhu, Y., Bu, P., Vancura, A., & Vancurova, I. (2018). The proto-oncogene Bcl3 induces immune checkpoint PD-L1 expression, mediating proliferation of ovarian cancer cells. Journal of Biological Chemistry, 293(40), 15483-15496.

Wang, V. Y. F., Li, Y., Kim, D., Zhong, X., Du, Q., Ghassemian, M., & Ghosh, G. (2017). Bcl3 phosphorylation by Akt, Erk2, and IKK is required for its transcriptional activity. Molecular cell, 67(3), 484-497.

Poveda, J., Sanz, A. B., Carrasco, S., Ruiz-Ortega, M., Cannata-Ortiz, P., Sanchez-Niño, M. D., & Ortiz, A. (2017). Bcl3: a regulator of NF-κB inducible by TWEAK in acute kidney injury with anti-inflammatory and antiapoptotic properties in tubular cells. Experimental & molecular medicine, 49(7), e352-e352.

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For research use only. Not intended for any clinical use.

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