BPI

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
Full Name
Bactericidal/Permeability-Increasing Protein
Function
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Biological Process
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cellular response to lipopolysaccharide Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Innate immune response Source: GO_Central
Lipopolysaccharide-mediated signaling pathway Source: GO_Central
Negative regulation of interleukin-6 production Source: BHF-UCL
Negative regulation of interleukin-8 production Source: BHF-UCL
Negative regulation of macrophage activation Source: BHF-UCL
Negative regulation of tumor necrosis factor production Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Cellular Location
Secreted; Cytoplasmic granule membrane. Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
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Anti-BPI antibodies

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Human BPI ELISA Kit (2) (V2LY-0626-LY717)

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Target: BPI
Sensitivity: 0.28 ng/mL
Detection Range: 0.5-150 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human BPI ELISA Kit (V2LY-0626-LY5500)

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Target: BPI
Sensitivity: 0.049 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Bpi ELISA Kit (V2LY-0626-LY1420)

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Target: Bpi
Sensitivity: 0.145 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Rat Bpi ELISA Kit (V2LY-0626-LY1249)

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Target: Bpi
Sensitivity: 0.0011 ng/mL
Detection Range: 0.002-0.6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Human Recombinant BPI protein, His Tag (V2LY-0526-LY2384)

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Target: BPI
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-487
Tag: His Tag
Datasheet SDS

Mouse Anti-BPI Recombinant Antibody (CBFYA-0151) (CBMAB-X0218-FY)

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Target: BPI
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYA-0151
Application*: FC, WB, IH
Datasheet SDS

Mouse Anti-BPI Recombinant Antibody (CBYY-2112) (CBMAB-2461-YY)

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Target: BPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-2112
Application*: E
Datasheet SDS

Mouse Anti-BPI Recombinant Antibody (CBYY-1767) (CBMAB-2116-YY)

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Target: BPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1767
Application*: E
Datasheet SDS

Mouse Anti-BPI Recombinant Antibody (CBYY-1687) (CBMAB-2036-YY)

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Target: BPI
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1687
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-BPI Recombinant Antibody (CBYY-0737) (CBMAB-0740-YY)

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Target: BPI
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-0737
Application*: WB, FC
Datasheet SDS

Mouse Anti-BPI Recombinant Antibody (CBYY-0736) (CBMAB-0739-YY)

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Target: BPI
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-0736
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-BPI Recombinant Antibody (CBYY-0733) (CBMAB-0736-YY)

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Target: BPI
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-0733
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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