BPI

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

Bactericidal/Permeability-Increasing Protein

The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.

Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cellular response to lipopolysaccharide Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Innate immune response Source: GO_Central
Lipopolysaccharide-mediated signaling pathway Source: GO_Central
Negative regulation of interleukin-6 production Source: BHF-UCL
Negative regulation of interleukin-8 production Source: BHF-UCL
Negative regulation of macrophage activation Source: BHF-UCL
Negative regulation of tumor necrosis factor production Source: BHF-UCL
Neutrophil degranulation Source: Reactome

Secreted; Cytoplasmic granule membrane. Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.