BPNT1

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq]

Full Name

3'(2'), 5'-bisphosphate nucleotidase 1

Function

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins1P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.

Biological Process

3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: Reactome
Inositol phosphate dephosphorylation Source: InterPro
Nervous system development Source: ProtInc
Nucleobase-containing compound metabolic process Source: ProtInc
Phosphatidylinositol phosphorylation Source: InterPro

Cellular Location

Cytosol