BRF1

BRF1 is one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. BRF1 belongs to the TF2B family.

Full Name

BRF1, RNA Polymerase III Transcription Initiation Factor Subunit

Function

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.

Biological Process

DNA-templated transcription, initiation Source: GO_Central
Positive regulation of transcription by RNA polymerase III Source: Ensembl
rRNA transcription Source: ProtInc
Transcription by RNA polymerase III Source: GO_Central
Transcription initiation from RNA polymerase III promoter Source: ProtInc
Transcription preinitiation complex assembly Source: InterPro
tRNA transcription Source: ProtInc

Cellular Location

Nucleus

Involvement in disease

Cerebellofaciodental syndrome (CFDS): An autosomal recessive disorder characterized by cerebellar hypoplasia, delayed development and intellectual disability, as well as facial dysmorphic features, short stature, microcephaly, and dental anomalies.