C5AR2
Full Name
complement component 5a receptor 2
Function
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Biological Process
Chemotaxis Source: InterPro
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of neutrophil chemotaxis Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of epithelial cell proliferation Source: InterPro
Positive regulation of ERK1 and ERK2 cascade Source: InterPro
Regulation of complement activation Source: Reactome
Regulation of interleukin-8 production Source: UniProtKB
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of neutrophil chemotaxis Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of epithelial cell proliferation Source: InterPro
Positive regulation of ERK1 and ERK2 cascade Source: InterPro
Regulation of complement activation Source: Reactome
Regulation of interleukin-8 production Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-38 aa
Helical: 39-61 aa
Cytoplasmic: 62-72 aa
Helical: 73-95 aa
Extracellular: 96-114 aa
Helical: 115-137 aa
Cytoplasmic: 138-149 aa
Helical: 150-172 aa
Extracellular: 173-202 aa
Helical: 203-225 aa
Cytoplasmic: 226-237 aa
Helical: 238-260 aa
Extracellular: 261-274 aa
Helical: 275-294 aa
Cytoplasmic: 295-337 aa
Helical: 39-61 aa
Cytoplasmic: 62-72 aa
Helical: 73-95 aa
Extracellular: 96-114 aa
Helical: 115-137 aa
Cytoplasmic: 138-149 aa
Helical: 150-172 aa
Extracellular: 173-202 aa
Helical: 203-225 aa
Cytoplasmic: 226-237 aa
Helical: 238-260 aa
Extracellular: 261-274 aa
Helical: 275-294 aa
Cytoplasmic: 295-337 aa
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Anti-C5AR2 antibodies
+ Filters
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CompareTarget: C5AR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-1522
Application*: FC
Target: C5AR2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBLG1-352
Application*: FC
Target: C5AR2
Host: Mouse
Antibody Isotype: IgG1, ĸ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0037
Application*: WB, IP, IF, E
Target: C5AR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3024
Application*: IH, IC, F
Target: C5AR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4026
Application*: WB, IH, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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