C5AR2

Full Name
complement component 5a receptor 2
Function
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Biological Process
Chemotaxis Source: InterPro
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of neutrophil chemotaxis Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of epithelial cell proliferation Source: InterPro
Positive regulation of ERK1 and ERK2 cascade Source: InterPro
Regulation of complement activation Source: Reactome
Regulation of interleukin-8 production Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-38 aa
Helical: 39-61 aa
Cytoplasmic: 62-72 aa
Helical: 73-95 aa
Extracellular: 96-114 aa
Helical: 115-137 aa
Cytoplasmic: 138-149 aa
Helical: 150-172 aa
Extracellular: 173-202 aa
Helical: 203-225 aa
Cytoplasmic: 226-237 aa
Helical: 238-260 aa
Extracellular: 261-274 aa
Helical: 275-294 aa
Cytoplasmic: 295-337 aa
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Anti-C5AR2 antibodies

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Mouse Anti-C5AR2 Recombinant Antibody (CBXC-1522) (CBMAB-C3517-CQ)

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Target: C5AR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-1522
Application*: FC
Datasheet SDS

Rat Anti-C5AR2 Recombinant Antibody (CBLG1-352) (CBMAB-G1312-LY)

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Target: C5AR2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBLG1-352
Application*: FC
Datasheet SDS

Mouse Anti-C5AR2 Recombinant Antibody (CBFYH-0037) (CBMAB-H0849-FY)

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Target: C5AR2
Host: Mouse
Antibody Isotype: IgG1, ĸ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0037
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-C5AR2 Recombinant Antibody (CBT3024) (V2LY-0625-LY1654)

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Target: C5AR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3024
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-C5AR2 Recombinant Antibody (CBT4026) (V2LY-0625-LY1653)

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Target: C5AR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4026
Application*: WB, IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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