CACNG7

CACNG7 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7) is a Protein Coding gene. Among its related pathways are Cardiac conduction and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG5.

Full Name

Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7

Function

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204).
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611).

Biological Process

Calcium ion transport Source: UniProtKB
Cardiac conduction Source: Reactome
Neurotransmitter receptor internalization Source: GO_Central
Neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: GO_Central
Positive regulation of dendrite extension Source: Ensembl
Positive regulation of synaptic transmission, glutamatergic Source: GO_Central
Postsynaptic neurotransmitter receptor diffusion trapping Source: GO_Central
Regulation of AMPA receptor activity Source: UniProtKB
Regulation of mRNA stability Source: Ensembl
Transmission of nerve impulse Source: GO_Central

Cellular Location

Cell membrane