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CALCOCO2

This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Full Name

Calcium Binding And Coiled-Coil Domain 2

Function

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324).
Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791).
Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791).
May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).

Biological Process

Positive regulation of autophagosome maturation Source: GO_Central
Response to interferon-gamma Source: BHF-UCL
Viral process Source: ProtInc
Xenophagy Source: GO_Central

Cellular Location

Cytoskeleton; Perinuclear region; Autophagosome membrane. According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.

Anti-CALCOCO2 antibodies

Mouse Anti-CALCOCO2 Recombinant Antibody (CBXC-2569) (CBMAB-C5342-CQ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: CBXC-2569

Application*: WB, IF, F

Mouse Anti-CALCOCO2 Recombinant Antibody (CBXC-1542) (CBMAB-C5341-CQ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXC-1542

Application*: E, IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBXC-2752) (CBMAB-C5339-CQ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBXC-2752

Application*: E, IH, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBXC-0044) (CBMAB-C5338-CQ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXC-0044

Application*: IF, E, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBXC-0045) (CBMAB-C3197-CQ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-0045

Application*: E, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBWJN-1056) (CBMAB-N0640-WJ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-1056

Application*: WB, IF, IP

Mouse Anti-CALCOCO2 Recombinant Antibody (CBWJN-1057) (CBMAB-N0641-WJ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-1057

Application*: WB, IF

Mouse Anti-CALCOCO2 Recombinant Antibody (CBWJN-1058) (CBMAB-N0642-WJ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-1058

Application*: WB

Mouse Anti-CALCOCO2 Recombinant Antibody (4H5) (CBMAB-N0643-WJ)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 4H5

Application*: WB, F, IF

Rabbit Anti-CALCOCO2 Recombinant Antibody (CBWJN-1059) (CBMAB-N0644-WJ)

SDS

Target: CALCOCO2

Host: Rabbit

Specificity: Human

Clone: CBWJN-1059

Application*: WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBFYC-0739) (CBMAB-C0794-FY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0739

Application*: DB, IC, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBFYC-0740) (CBMAB-C0795-FY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0740

Application*: F, IF, WB

Mouse Anti-CALCOCO2 (AA 347-446) Recombinant Antibody (CBFYC-0741) (CBMAB-C0796-FY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-0741

Application*: E, IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBYY-C0891) (CBMAB-C2328-YY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYY-C0891

Application*: E, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBYY-C0893) (CBMAB-C2330-YY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C0893

Application*: F, IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (CBYY-C3207) (CBMAB-C4650-YY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C3207

Application*: IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (P17410) (CBMAB-C9641-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: P17410

Application*: WB

Mouse Anti-CALCOCO2 Recombinant Antibody (P1813) (CBMAB-C9642-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: P1813

Application*: IC, IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (P422) (CBMAB-C9643-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: P422

Application*: IC, IF, IP, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (2H5) (CBMAB-A1043-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2H5

Application*: WB, E

Rabbit Anti-CALCOCO2 Recombinant Antibody (D1E4A) (CBMAB-CP1658-LY)

SDS

Target: CALCOCO2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D1E4A

Application*: WB

Mouse Anti-CALCOCO2 Recombinant Antibody (2F2C2) (CBMAB-AP746LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 2F2C2

Application*: ELISA, IHC, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (2623C2_2a) (CBMAB-C0760-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2623C2_2a

Application*: DB, C, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (1A11) (CBMAB-C3508-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A11

Application*: E, IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (2B11) (CBMAB-C4654-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2B11

Application*: F, IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (2D11) (CBMAB-C4856-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Rat, Monkey

Clone: 2D11

Application*: F, IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (3C4) (CBMAB-C5808-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3C4

Application*: E, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (3F2) (CBMAB-C6021-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3F2

Application*: IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (6E8) (CBMAB-C8252-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6E8

Application*: IF, WB

Mouse Anti-CALCOCO2 Recombinant Antibody (7A7) (CBMAB-C8563-LY)

SDS

Target: CALCOCO2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 7A7

Application*: F, IF, WB

CALCOCO2 Matched Antibody Pair (167) (APMAB-167LY)

SDS

Target: CALCOCO2

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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