CALCOCO2

This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Full Name
Calcium Binding And Coiled-Coil Domain 2
Function
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324).
Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791).
Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791).
May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).
Biological Process
Positive regulation of autophagosome maturation Source: GO_Central
Response to interferon-gamma Source: BHF-UCL
Viral process Source: ProtInc
Xenophagy Source: GO_Central
Cellular Location
Cytoskeleton; Perinuclear region; Autophagosome membrane. According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.
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Anti-CALCOCO2 antibodies

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Rabbit Anti-CALCOCO2 Recombinant Antibody (D1E4A) (CBMAB-CP1658-LY)

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Target: CALCOCO2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1E4A
Application*: WB
Datasheet SDS

Mouse Anti-CALCOCO2 Recombinant Antibody (3C4) (CBMAB-C5808-LY)

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Target: CALCOCO2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C4
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-CALCOCO2 Recombinant Antibody (1A11) (CBMAB-C3508-LY)

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Target: CALCOCO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1A11
Application*: E, IF, WB
Datasheet SDS

CALCOCO2 Matched Antibody Pair (167) (APMAB-167LY)

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Target: CALCOCO2
Specificity: Human
Datasheet SDS

Mouse Anti-CALCOCO2 Recombinant Antibody (CBFYC-0741) (CBMAB-C0796-FY)

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Target: CALCOCO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-0741
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-CALCOCO2 Recombinant Antibody (CBFYC-0740) (CBMAB-C0795-FY)

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Target: CALCOCO2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0740
Application*: E, WB
Datasheet SDS

Mouse Anti-CALCOCO2 Recombinant Antibody (CBFYC-0739) (CBMAB-C0794-FY)

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Target: CALCOCO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-0739
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-CALCOCO2 Recombinant Antibody (CBWJN-1058) (CBMAB-N0642-WJ)

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Target: CALCOCO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-1058
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CALCOCO2 Recombinant Antibody (CBWJN-1057) (CBMAB-N0641-WJ)

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Target: CALCOCO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-1057
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CALCOCO2 Recombinant Antibody (CBWJN-1056) (CBMAB-N0640-WJ)

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Target: CALCOCO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-1056
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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