CAPRIN1

CAPRIN1 (Cell Cycle Associated Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is CAPRIN2.

Full Name

Cell Cycle Associated Protein 1

Function

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.

Biological Process

Negative regulation of translation Source: UniProtKB
Positive regulation of dendrite morphogenesis Source: UniProtKB
Positive regulation of dendritic spine morphogenesis Source: UniProtKB

Cellular Location

Cytosol; Dendrite; Lamellipodium. Associated with RNA granules. At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330).

PTM

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.