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Mouse Anti-CAPRIN1 Recombinant Antibody (6B10F11) (CBMAB-AP773LY)


See all CAPRIN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
6B10F11
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion Protein of CAPRIN1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cell Cycle Associated Protein 1
Introduction
CAPRIN1 (Cell Cycle Associated Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is CAPRIN2.
Entrez Gene ID
Human4076
Mouse53872
Rat362173
UniProt ID
HumanQ14444
MouseQ60865
RatQ5M9G3
Alternative Names
Cell Cycle Associated Protein 1; GPI-Anchored Membrane Protein 1; Cytoplasmic Activation- And Proliferation-Associated Protein 1; Cytoplasmic Activation/Proliferation-Associated Protein-1; Membrane Component Chromosome 11 Surface Marker 1; GPI-Anchored Protein P137; RNA Granule Protein 105; GPI-P137; GPIP137; P137GPI;
Function
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Biological Process
Negative regulation of translation Source: UniProtKB
Positive regulation of dendrite morphogenesis Source: UniProtKB
Positive regulation of dendritic spine morphogenesis Source: UniProtKB
Cellular Location
Cytosol; Dendrite; Lamellipodium. Associated with RNA granules. At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330).
PTM
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Luo, H. L., Luo, T., Liu, J. J., Wu, F. X., Bai, T., Ou, C., ... & Zhong, J. H. (2021). Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway. Cancer cell international, 21(1), 1-16.

Yu, X., He, Y., Wang, Y., Tang, Y., Guo, Y., Yuan, J., ... & Wu, X. (2020). MicroRNA-199a-5p suppresses the cell growth of colorectal cancer by targeting oncogene Caprin1. 3 Biotech, 10(10), 1-10.

Lee, Y. Z., Guo, H. C., Zhao, G. H., Yang, C. W., Chang, H. Y., Yang, R. B., ... & Lee, S. J. (2020). Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1α. Pharmacological research, 152, 104581.

Guo, X. M., Zhu, F. F., Pan, L. W., Chen, J. L., Lai, J. C., Wu, H. X., & Shu, J. C. (2020). Caprin‑1 promotes HepG2 cell proliferation, invasion and migration and is associated with poor prognosis in patients with liver cancer. Oncology Letters, 20(2), 1761-1771.

Yang, Z. S., Qing, H., Gui, H., Luo, J., Dai, L. J., & Wang, B. (2019). Role of caprin‑1 in carcinogenesis. Oncology letters, 18(1), 15-21.

Zhang, L., Gui, H., Tang, X. J., Yang, Z. S., Zou, D. D., Lu, J. T., ... & Wang, B. (2018). Expression and tumor-Promoting effects of caprin-1 in human glioma. Glioma, 1(4), 136.

Zhang, Y., You, W., Zhou, H., Chen, Z., Han, G., Zuo, X., ... & Wang, X. (2018). Downregulated miR-621 promotes cell proliferation via targeting CAPRIN1 in hepatocellular carcinoma. American journal of cancer research, 8(10), 2116.

Copsey, A. C., Cooper, S., Parker, R., Lineham, E., Lapworth, C., Jallad, D., ... & Morley, S. J. (2017). The helicase, DDX3X, interacts with poly (A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading. Biochemical Journal, 474(18), 3109-3120.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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