CCL15

This gene, CCL15, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene is chemotactic for T cells and monocytes and induces N-acetyl-beta-D-glucosaminidase release in monocytes. It induces changes in intracellular calcium concentration in monocytes and is thought to act through the CCR1 receptor. Read-through transcripts are expressed that include exons from the downstream cytokine gene CCL14, and are represented as GeneID: 348249. [provided by RefSeq]
Full Name
chemokine (C-C motif) ligand 15
Function
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
Biological Process
Cell-cell signaling Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Secreted
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Anti-CCL15 antibodies

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Mouse Anti-CCL15 Recombinant Antibody (CBYY-C1061) (CBMAB-C2498-YY)

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Target: CCL15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1061
Application*: E
Datasheet SDS

Mouse Anti-CCL15 Recombinant Antibody (3B7) (CBMAB-A1170-LY)

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Target: CCL15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B7
Application*: E
Datasheet SDS

Mouse Anti-CCL15 Recombinant Antibody (C9800) (CBMAB-C9800-LY)

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Target: CCL15
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C9800
Application*: E, WB
Datasheet SDS

Rabbit Anti-CCL15 Recombinant Antibody (CBFYC-0934) (CBMAB-C0990-FY)

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Target: CCL15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0934
Application*: E
Datasheet SDS

Mouse Anti-CCL15 Recombinant Antibody (CBFYC-0933) (CBMAB-C0989-FY)

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Target: CCL15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0933
Application*: E
Datasheet SDS

Mouse Anti-CCL15 Recombinant Antibody (CBFYM-0904) (CBMAB-M1052-FY)

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Target: CCL15
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-0904
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CCL15 Recombinant Antibody (52130) (CBMAB-C7152-LY)

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Target: CCL15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 52130
Application*: WB, N, E
Functional Assay
Datasheet SDS

Mouse Anti-CCL15 Recombinant Antibody (1D7) (CBMAB-C3856-LY)

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Target: CCL15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D7
Application*: E, WB
Datasheet SDS

Rabbit Anti-CCL15 Recombinant Antibody (1) (CBMAB-C1904-LY)

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Target: CCL15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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