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CD14

CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Mycobacterium Chelonae and Croup. Among its related pathways are Bacterial infections in CF airways and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.
Full Name
CD14 Molecule
Function
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655).
In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655, PubMed:22265692).
Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135).
Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- (PubMed:23880187).
Biological Process
Apoptotic process Source: ProtInc
Apoptotic signaling pathway Source: Reactome
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to diacyl bacterial lipopeptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: MGI
Cellular response to lipoteichoic acid Source: MGI
Cellular response to molecule of bacterial origin Source: CAFA
Cellular response to triacyl bacterial lipopeptide Source: UniProtKB
I-kappaB kinase/NF-kappaB signaling Source: Reactome
Inflammatory response Source: GO_Central
Innate immune response Source: UniProtKB-KW
Lipopolysaccharide-mediated signaling pathway Source: GO_Central
MyD88-dependent toll-like receptor signaling pathway Source: Reactome
MyD88-independent toll-like receptor signaling pathway Source: Reactome
Necroptotic process Source: Reactome
Negative regulation of MyD88-independent toll-like receptor signaling pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Phagocytosis Source: ProtInc
Positive regulation of endocytosis Source: Ensembl
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-8 production Source: CAFA
Positive regulation of NIK/NF-kappaB signaling Source: AgBase
Positive regulation of tumor necrosis factor production Source: AgBase
Positive regulation of type I interferon production Source: GO_Central
Receptor-mediated endocytosis Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to ethanol Source: Ensembl
Response to heat Source: Ensembl
Response to magnesium ion Source: Ensembl
Response to tumor necrosis factor Source: Ensembl
Toll-like receptor 4 signaling pathway Source: UniProtKB
Toll-like receptor signaling pathway Source: Reactome
Toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
Toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Cellular Location
Golgi apparatus; Secreted; Cell membrane; Membrane raft. Secreted forms may arise by cleavage of the GPI anchor.
PTM
N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

Anti-CD14 antibodies

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Target: CD14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: N418
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: RM052
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Sheep, Cattle
Clone: VPM67
Application*: E, F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Sheep, Goat, Cattle
Clone: VPM65
Application*: C, E, IP, F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: RoMo-1
Application*: F
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP192
Application*: WB, P
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: biG53
Application*: F
Target: CD14
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: Sa2-8
Application*: F
Target: CD14
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: rmC5-3
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A3B6
Application*: E, IH
Target: CD14
Host: Mouse
Specificity: Human
Clone: CBCNC-159
Application*: E, FC, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: X-8
Application*: IH, FC, P
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: Tuk 4
Application*: FC
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C1172
Application*: F, IF, IH, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1171
Application*: IF, IH, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1170
Application*: E, F, IP, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C1169
Application*: E(Det)
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 87H7
Application*: WB, F, E
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0654
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0473
Application*: F, IH, IP
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0436
Application*: F, IH, IP
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0374
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYY-C0373
Application*: F, IF
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A3H5D5
Application*: E, F, P
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A3B11B5
Application*: E, IH
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0304
Application*: E(Cap)
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 4B4F12
Application*: E, F, P, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0269
Application*: IF, F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 47-3D6
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Dog, Goat, Human, Monkey, Pig, Rabbit, Sheep
Clone: CBYY-C0169
Application*: E, F, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: CBYY-C0168
Application*: F, IF, IH, IP
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1109
Application*: P
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1108
Application*: WB, E, ED
Target: CD14
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-1107
Application*: F, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Dog, Goat, Human, Mouse, Pig, Rabbit, Sheep
Clone: CBFYC-1105
Application*: E, F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1102
Application*: F, FN
Target: CD14
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0308
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0229
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig, Cattle, Dog, Cattle, Goat, Llama, Mustelid, Primate, Rabbit, Sheep
Clone: CBFYC-0204
Application*: F, E
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBFYC-0189
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Pig
Clone: CBFYC-0188
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0008
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Pig
Clone: 8B7
Application*: E, C, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 6D253
Application*: E, F
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 217
Application*: EC
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 2
Application*: E, WB
Target: CD14
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L157
Application*: C, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Horse, Human
Clone: 13A248
Application*: E, C, WB
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 503
Application*: F, IC/IF, IF
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Pig, Horse
Clone: 433423
Application*: WB, F, MC
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Dog, Human, Monkey, Pig, Rabbit, Sheep
Clone: 3H501
Application*: E, C, WB
Target: CD14
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 159010
Application*: WB, F, MC
Target: CD14
Host: Mouse
Specificity: Rat
Clone: CBFYM-0970
Application*: WB, IC, P, C, E
Target: CD14
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Horse, Cattle
Clone: CBFYM-0969
Application*: E, WB
Target: CD14
Host: Mouse
Specificity: Human
Clone: CBFYM-0968
Application*: WB, IC, P, C, E
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-0102
Application*: F
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPR3653
Application*: ELISA
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: Mab0211
Application*: IH, FC
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9L92
Application*: E, FC, IP, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: 9G141
Application*: FC
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F16
Application*: FC, IF
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L156
Application*: N, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13H49
Application*: FC, IF
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B113
Application*: E, IH
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Fish, Human, Monkey, Trout
Clone: UCHM1
Application*: FC
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: FWKW
Application*: FC
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BS9
Application*: P
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-A8
Application*: E, P, FC
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-18
Application*: B, E, C, FN, IP, N, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8J227
Application*: E, F, IP, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H221
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7
Application*: C, P
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D251
Application*: E, F, IP
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Dog, Horse, Guinea pig, Pig
Clone: 6D250
Application*: E, C, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 63D3
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 61D3
Application*: C, FN, P
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5K63
Application*: F, IH, IP
Target: CD14
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 5F15
Application*: F, IF
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5D8
Application*: F, IF, IH
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A3
Application*: E, P
Target: CD14
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 55-3
Application*: EC
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 50008
Application*: B/N
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H53
Application*: N, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4 E4
Application*: F, IF, C, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4 E11
Application*: IF, C, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H504
Application*: E, F, IP, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q1233
Application*: C, F, IC/IF
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1H5D8
Application*: WB, P, IC/IF
Target: CD14
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 14i96
Application*: E, F, C, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14i95
Application*: E, C, WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 50025
Application*: WB
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Dog, Ferret, Monkey, Pig, Rabbit, Sheep
Clone: 10B734
Application*: E, F
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 107
Application*: E
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1.B.10
Application*: F
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 01
Application*: E
Target: CD14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 001
Application*: P
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4AW4
Application*: IF/C, F
Target: CD14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H493
Application*: F, IH, IP
Target: CD14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 134620
Application*: WB, F, N, MC
Target: CD14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 11E72
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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