CD1E

CD1E (CD1e Molecule) is a Protein Coding gene. Diseases associated with CD1E include Mycobacterium Malmoense and Autoimmune Neuropathy. Among its related pathways are Hematopoietic cell lineage and Tight junction. Gene Ontology (GO) annotations related to this gene include lipid binding and lipopeptide binding. An important paralog of this gene is CD1B.

Full Name

CD1e Molecule

Function

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central

Cellular Location

T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Early endosome; Late endosome. Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.
T-cell surface glycoprotein CD1e, soluble: Lysosome lumen

Topology

Helical: 305-325

PTM

Mono-ubiquitinated.
Proteolytically cleaved in late endosomes to yield a soluble form.

Anti-CD1E antibodies

Rabbit Anti-CD1E Recombinant Antibody (EG533) (CBMAB-EN618-LY)

Datasheet

SDS

Target: CD1E

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG533

Application*: WB: 1:500~1:1000 ELISA: 1:10000

Mouse Anti-CD1E Recombinant Antibody (CBXC-1298) (CBMAB-C1565-CQ)

Datasheet

SDS

Target: CD1E

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-1298

Application*: IS

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)