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Rabbit Anti-CD1E Recombinant Antibody (EG533) (CBMAB-EN618-LY)

The product is antibody recognizes CD1E . The antibody EG533 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all CD1E antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG533
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CD1E.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD1e Molecule
Introduction
CD1E (CD1e Molecule) is a Protein Coding gene. Diseases associated with CD1E include Mycobacterium Malmoense and Autoimmune Neuropathy. Among its related pathways are Hematopoietic cell lineage and Tight junction. Gene Ontology (GO) annotations related to this gene include lipid binding and lipopeptide binding. An important paralog of this gene is CD1B.
Entrez Gene ID
913
UniProt ID
P15812
Alternative Names
CD1e Molecule; CD1E Antigen, E Polypeptide; CD1e Antigen; HCD1e; R2G1; T-Cell Surface Glycoprotein CD1e, Membrane-Associated;
Function
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Cellular Location
T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Early endosome; Late endosome. Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.
T-cell surface glycoprotein CD1e, soluble: Lysosome lumen
Topology
Helical: 305-325
PTM
Mono-ubiquitinated.
Proteolytically cleaved in late endosomes to yield a soluble form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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