CD8
CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 consists of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Alpha and beta chains have a strong homology to immunoglobulins with variable light channels. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. The alpha chains of CD8 bind to the alpha domains of classI MHC molecules, alpha 3.
Full Name
Cluster of differentiation 8
Alternative Names
CD8
Anti-CD8 antibodies
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CompareTarget: CD8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: C1083
Application*: IF, IP, WB, F
Target: CD8 (Lyt 2.1)
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 0999
Application*: WB, in vivo
Target: CD8
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AG40
Application*: F, C, WB
Target: CD8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-170
Target: CD8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-170
Target: CD8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-170
Tag: hFc Tag
Target: CD8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4602
Application*: WB
Target: CD8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2729
Application*: F
Target: CD8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cat, Human
Clone: 80
Application*: P
Target: CD8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: C7680
Application*: F
Target: CD8
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: C6365
Application*: in vivo, FC, WB, IF
Target: CD8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: C2337
Application*: E, P
Target: CD8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C1375
Application*: IF, F, P
Target: CD8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C1357
Application*: IF, F, P
Target: CD8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: 37006
Application*: IF, IP, WB, F, P
Target: CD8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: C0978
Application*: F, in vivo
Target: CD8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: C0799
Application*: in vivo, FC, IH
Target: CD8
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 2.43
Application*: WB, in vivo
Target: CD8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: C0432
Application*: WB, in vivo
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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