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Rat Anti-CD8 Recombinant Antibody (AG40) (V2LY-0524-LY115)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
AG40
Antibody Isotype
IgG2b, κ
Application
FC, IHC-F, WB

Basic Information

Immunogen
CBA mouse thymocytes
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
< 1.0 EU/mg as determined by the LAL method
Format
Liquid
Buffer
PBS
Preservative
None
Concentration
5 mg/ml
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cluster of differentiation 8
Introduction
CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 consists of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Alpha and beta chains have a strong homology to immunoglobulins with variable light channels. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. The alpha chains of CD8 bind to the alpha domains of classI MHC molecules, alpha 3.
Alternative Names
CD8
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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