CDK11A

CDK11A (Cyclin Dependent Kinase 11A) is a Protein Coding gene. Diseases associated with CDK11A include Neuroblastoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK11B.

Full Name

Cyclin Dependent Kinase 11A

Function

Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.

Biological Process

Apoptotic process Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell growth Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Regulation of mRNA processing Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus

PTM

During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins.