CDKN2B

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Cell cycle arrest Source: BHF-UCL
Cellular response to extracellular stimulus Source: BHF-UCL
Cellular response to nutrient Source: BHF-UCL
Cellular senescence Source: BHF-UCL
G2/M transition of mitotic cell cycle Source: BHF-UCL
Megakaryocyte differentiation Source: UniProtKB
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of epithelial cell proliferation Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: Reactome
Negative regulation of phosphorylation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: Reactome
Positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Regulation of G0 to G1 transition Source: BHF-UCL
Spleen development Source: Ensembl

Cytoplasm. Also found in the nucleus.