CDKN2B

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]
Full Name
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Function
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
Biological Process
Cell cycle arrest Source: BHF-UCL
Cellular response to extracellular stimulus Source: BHF-UCL
Cellular response to nutrient Source: BHF-UCL
Cellular senescence Source: BHF-UCL
G2/M transition of mitotic cell cycle Source: BHF-UCL
Megakaryocyte differentiation Source: UniProtKB
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of epithelial cell proliferation Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: Reactome
Negative regulation of phosphorylation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: Reactome
Positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Regulation of G0 to G1 transition Source: BHF-UCL
Spleen development Source: Ensembl
Cellular Location
Cytoplasm. Also found in the nucleus.
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Anti-CDKN2B antibodies

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Mouse Anti-CDKN2B Recombinant Antibody (CBYY-C1812) (CBMAB-C3250-YY)

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Target: CDKN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1812
Application*: IP, P, WB
Datasheet SDS

Mouse Anti-CDKN2B Recombinant Antibody (CBYY-C1811) (CBMAB-C3249-YY)

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Target: CDKN2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C1811
Application*: E, WB
Datasheet SDS

Mouse Anti-CDKN2B Recombinant Antibody (CBYY-C1810) (CBMAB-C3248-YY)

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Target: CDKN2B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C1810
Application*: IF, WB
Datasheet SDS

Mouse Anti-CDKN2B Recombinant Antibody (CBYY-C1809) (CBMAB-C3247-YY)

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Target: CDKN2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C1809
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-CDKN2B Recombinant Antibody (CBFYC-1644) (CBMAB-C1705-FY)

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Target: CDKN2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-1644
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN2B Recombinant Antibody (8C4) (CBMAB-C9079-LY)

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Target: CDKN2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8C4
Application*: E, WB
Datasheet SDS

Human CDKN2B ELISA Kit (V2LY-0626-LY4459)

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Target: CDKN2B
Sensitivity: 0.0094 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant CDKN2B protein, GST Tag (V2LY-0526-LY3071)

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Target: CDKN2B
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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