CEACAM2

Full Name

Carcinoembryonic antigen related cell adhesion molecule 5

Function

Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus.
Isoform 2 may be an adhesion molecule contributing to cell to cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium.

Biological Process

Energy homeostasis Source: MGI
Negative regulation of brown fat cell proliferation Source: MGI
Negative regulation of feeding behavior Source: MGI
Viral process Source: UniProtKB-KW

Cellular Location

Cell membrane; Localizes to sites on the plasma membrane of elongating spermatids where Sertoli cells make contact.

Topology

Extracellular: 35-422
Helical: 423-443
Cytoplasmic: 444-520