Rat Anti-CEACAM2 Recombinant Antibody (CBYY-C0743) (CBMAB-C2179-YY)

Name: Rat Anti-CEACAM2 Recombinant Antibody (CBYY-C0743)
SKU: CBMAB-C2179-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYY-C0743

Application

Immunogen

Recombinant mouse CEACAM-2, Gln35-Asp422.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
FC	0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, 5% trehalose

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic antigen related cell adhesion molecule 5

Entrez Gene ID

26367

UniProt ID

Q925P2

Alternative Names

Baculoviral IAP Repeat Containing 2; RING-Type E3 Ubiquitin Transferase BIRC2; TNFR2-TRAF-Signaling Complex Protein 2; NFR2-TRAF Signalling Complex Protein; Cellular Inhibitor Of Apoptosis 1; Inhibitor Of Apoptosis Protein 2; RING Finger Protein 48; Apoptosis Inhibitor 1; IAP Homolog B; Hiap-2; C-IAP1;

Function

Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus.
Isoform 2 may be an adhesion molecule contributing to cell to cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium.

Biological Process

Energy homeostasis Source: MGI
Negative regulation of brown fat cell proliferation Source: MGI
Negative regulation of feeding behavior Source: MGI
Viral process Source: UniProtKB-KW

Cellular Location

Cell membrane; Localizes to sites on the plasma membrane of elongating spermatids where Sertoli cells make contact.

Topology

Extracellular: 35-422
Helical: 423-443
Cytoplasmic: 444-520

Salaheldeen, E., Jaume, A., & Michael Najjar, S. (2019). Carcinoembryonic cell adhesion-related molecule 2 regulates insulin secretion and energy balance. International journal of molecular sciences, 20(13), 3231.

Ghanem, S. S. (2017). A Role for CEACAM2 protein in Insulin Secretion, Clearance and Action (Doctoral dissertation, University of Toledo).

Ghanem, S. S., Muturi, H. T., DeAngelis, A. M., Hu, J., Kulkarni, R. N., Heinrich, G., & Najjar, S. M. (2017). Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene. Diabetologia, 60(9), 1751-1760.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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