CENPV

CENPV (Centromere Protein V) is a Protein Coding gene. Diseases associated with CENPV include Intracranial Primitive Neuroectodermal Tumor and Diffuse Glomerulonephritis. Gene Ontology (GO) annotations related to this gene include carbon-sulfur lyase activity. An important paralog of this gene is CENPVL3.

Full Name

centromere protein V

Function

Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.

Biological Process

Ameboidal-type cell migration Source: MGI
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Centromere complex assembly Source: UniProtKB
Pericentric heterochromatin assembly Source: UniProtKB
Positive regulation of cytokinesis Source: UniProtKB
Regulation of chromosome organization Source: UniProtKB

Cellular Location

Spindle; Nucleus; Kinetochore. Enriched at the nuclear periphery and around the nucleolus (PubMed:12196509). In mitotic cells, localizes to kinetochores from prometaphase to metaphase (PubMed:18772885). At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis (PubMed:18772885).