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Mouse Anti-CENPV Recombinant Antibody (CBFYC-1722) (CBMAB-C1784-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1722
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
CENPV (173 a.a.-272 a.a) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
centromere protein V
Introduction
CENPV (Centromere Protein V) is a Protein Coding gene. Diseases associated with CENPV include Intracranial Primitive Neuroectodermal Tumor and Diffuse Glomerulonephritis. Gene Ontology (GO) annotations related to this gene include carbon-sulfur lyase activity. An important paralog of this gene is CENPVL3.
Entrez Gene ID
201161
UniProt ID
Q7Z7K6
Alternative Names
Centromere Protein V; Proline-Rich Protein 6; Nuclear Protein P30; Proline Rich 6; CENP-V; PRR6; 3110013H01Rik; P30
Function
Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.
Biological Process
Ameboidal-type cell migration Source: MGI
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Centromere complex assembly Source: UniProtKB
Pericentric heterochromatin assembly Source: UniProtKB
Positive regulation of cytokinesis Source: UniProtKB
Regulation of chromosome organization Source: UniProtKB
Cellular Location
Spindle; Nucleus; Kinetochore. Enriched at the nuclear periphery and around the nucleolus (PubMed:12196509). In mitotic cells, localizes to kinetochores from prometaphase to metaphase (PubMed:18772885). At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis (PubMed:18772885).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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