CES3

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
Full Name
Carboxylesterase 3
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Biological Process
Lipid catabolic process Source: GO_Central
Low-density lipoprotein particle clearance Source: Reactome
Xenobiotic metabolic process Source: Reactome
Cellular Location
Endoplasmic reticulum lumen
PTM
N-glycosylated.
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Anti-CES3 antibodies

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Mouse Anti-CES3 Recombinant Antibody (CBWJC-2511) (CBMAB-C3582WJ)

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Target: CES3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJC-2511
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CES3 Recombinant Antibody (CBFYC-1735) (CBMAB-C1797-FY)

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Target: CES3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1735
Application*: E
Datasheet SDS

Rabbit Anti-CES3 Recombinant Antibody (372) (CBMAB-C5583-LY)

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Target: CES3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 372
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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