CLC

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

Charcot-Leyden Crystal Galectin

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).

Multicellular organism development Source: ProtInc
Regulation of activated T cell proliferation Source: UniProtKB
Regulation of T cell anergy Source: UniProtKB
Regulation of T cell cytokine production Source: UniProtKB
T cell apoptotic process Source: UniProtKB

Cytosol; Cytoplasmic granule. Localized in granules from where it may be secreted or transported to other locations in the cell.