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CLDN3

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Full Name
Claudin 3
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Actin cytoskeleton reorganization Source: ARUK-UCL
Bicellular tight junction assembly Source: UniProtKB
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: Ensembl
Cell adhesion Source: GO_Central
Cell junction maintenance Source: ARUK-UCL
Epithelial cell morphogenesis Source: UniProtKB
Establishment of endothelial blood-brain barrier Source: ARUK-UCL
Maintenance of blood-brain barrier Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ARUK-UCL
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of wound healing Source: ARUK-UCL
Positive regulation of bicellular tight junction assembly Source: ARUK-UCL
Positive regulation of cell junction assembly Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of metallopeptidase activity Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Positive regulation of wound healing Source: ARUK-UCL
Regulation of cell morphogenesis Source: ARUK-UCL
Regulation of membrane permeability Source: ARUK-UCL
Regulation of transepithelial transport Source: ARUK-UCL
Response to ethanol Source: Ensembl
Response to hypoxia Source: UniProtKB
Cellular Location
Cell membrane; Tight junction
Involvement in disease
CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Topology
Cytoplasmic: 1-8
Helical: 9-29
Extracellular: 30-80
Helical: 81-101
Cytoplasmic: 102-115
Helical: 116-136
Extracellular: 137-159
Helical: 160-180
Cytoplasmic: 181-220

Anti-CLDN3 antibodies

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Target: CLDN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1E7
Application*: P, WB
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNC-189
Application*: E, E-capture, WB
Target: CLDN3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D7A3O
Application*: WB, IP, IF (IC)
Target: CLDN3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG721
Application*: WB: 1:500~1:1000 ELISA: 1:1000
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1904
Application*: P
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1905
Application*: E
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-2766
Application*: WB
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2D4
Application*: WB
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 385021
Application*: F, IH, IC, MC
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6H1
Application*: IHC
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: PT0111
Application*: IHC
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1158
Application*: F
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0458
Application*: SE, WB, E
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1987
Application*: WB, IH
Target: CLDN3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1717
Application*: WB, IP, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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