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CLEC4E

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Full Name

C-Type Lectin Domain Family 4 Member E

Function

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766).

The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491).

Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity).

Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity).

Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (By similarity).

Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity).

Biological Process

Innate immune response Source: UniProtKB-KW
Pattern recognition receptor signaling pathway Source: UniProtKB
Stimulatory C-type lectin receptor signaling pathway Source: Reactome

Cellular Location

Cell membrane; Phagocytic cup

Topology

Cytoplasmic: 1-19
Helical: 20-40
Extracellular: 41-219

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Anti-CLEC4E antibodies

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Human CLEC4E ELISA Kit (V2LY-0626-LY586)

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Target: CLEC4E

Sensitivity: 0.0023 ng/mL

Detection Range: 0.005-2 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Rhesus Recombinant CLEC4E protein, ECD, hFc Tag (V2LY-0526-LY9694)

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Target: CLEC4E

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 41-219

Tag: hFc Tag

Mouse Anti-CLEC4E Recombinant Antibody (CBYY-C3153) (V2LY-1206-LY150)

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Target: CLEC4E

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C3153

Application*: WB

Mouse Anti-CLEC4E Recombinant Antibody (CBFYC-1926) (V2LY-1206-LY149)

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Target: CLEC4E

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-1926

Application*: F, WB

Mouse Anti-CLEC4E Recombinant Antibody (CBLC-LY-013) (V2LY-1206-LY147)

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Target: CLEC4E

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: CBLC-LY-013

Application*: WB, IP, IF, E

Mouse Anti-CLEC4E Recombinant Antibody (2D12) (V2LY-1206-LY146)

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Target: CLEC4E

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2D12

Application*: E, WB

Mouse Anti-CLEC4E Recombinant Antibody (16E3) (V2LY-1206-LY145)

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Target: CLEC4E

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Rat

Clone: 16E3

Application*: E, IF, F, P, WB

Mouse Anti-CLEC4E Recombinant Antibody (CBFYM-1013) (V2LY-1206-LY144)

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Target: CLEC4E

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-1013

Application*: E, IF, IP, P, WB

Mouse Anti-CLEC4E Recombinant Antibody (CBFYC-0317) (CBMAB-C0353-FY)

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Target: CLEC4E

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: CBFYC-0317

Application*: E, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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