CNOT8

CNOT8 (CCR4-NOT Transcription Complex Subunit 8) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT7.

Full Name

CCR4-NOT transcription complex, subunit 8

Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Exonucleolytic catabolism of deadenylated mRNA Source: UniProtKB
Gene silencing by miRNA Source: UniProtKB
Negative regulation of translation Source: GO_Central
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of mRNA catabolic process Source: BHF-UCL
Transcription, DNA-templated Source: InterPro

Cellular Location

Nucleus; Cytoplasm