COG7

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002 [PubMed 11980916]).[supplied by OMIM

Full Name

component of oligomeric golgi complex 7

Function

Required for normal Golgi function.

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Golgi organization Source: GO_Central
Intracellular protein transport Source: UniProtKB
Protein glycosylation Source: UniProtKB
Protein localization to Golgi apparatus Source: UniProtKB
Protein localization to organelle Source: UniProtKB
Protein stabilization Source: UniProtKB
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: UniProtKB

Cellular Location

Golgi apparatus membrane

Involvement in disease

Congenital disorder of glycosylation 2E (CDG2E):
A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.