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CYB5A

CYB5A (Cytochrome B5 Type A) is a Protein Coding gene. Diseases associated with CYB5A include Methemoglobinemia Type Iv and Adrenal Hyperplasia, Congenital, Due To 17-Alpha-Hydroxylase Deficiency. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include enzyme binding and cytochrome-c oxidase activity. An important paralog of this gene is CYB5B.

Full Name

Cytochrome B5 Type A

Function

Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.

Biological Process

L-ascorbic acid metabolic process Source: Reactome
Protein insertion into ER membrane Source: Reactome
Response to cadmium ion Source: Ensembl

Cellular Location

Isoform 1: Endoplasmic reticulum membrane; Microsome membrane
Isoform 2: Cytoplasm

Involvement in disease

Methemoglobinemia and ambiguous genitalia (METAG):
An autosomal recessive disorder characterized by sex steroid deficiency but normal glucocorticoid and mineralocorticoid reserve, male undermasculinization, absent or disturbed pubertal development, decreased levels of erythrocyte cytochrome B5, and excessive amounts of methemoglobin in blood cells resulting in cyanosis and hypoxia.

Topology

Helical: 109-131

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Anti-CYB5A antibodies

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Mouse Anti-CYB5A Recombinant Antibody (CBXC-1912) (CBMAB-C3795-CQ)

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Target: CYB5A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-1912

Application*: E, WB, IH

Mouse Anti-CYB5A Recombinant Antibody (CBFYC-2551) (CBMAB-C2625-FY)

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Target: CYB5A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-2551

Application*: E, WB

Human CYB5A ELISA Kit (V2LY-0626-LY4469)

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Target: CYB5A

Sensitivity: 0.007 ng/mL

Detection Range: 0.015-3 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Anti-CYB5A Recombinant Antibody (CBYY-C3177) (V2LY-0125-LY832)

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Target: CYB5A

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYY-C3177

Application*: WB, IP, IF, E, P

Mouse Anti-CYB5A Recombinant Antibody (4C2) (V2LY-0125-LY830)

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Target: CYB5A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4C2

Application*: E, P, WB, IP

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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