CYP8B1

CYP8B1 (Cytochrome P450 Family 8 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP8B1 include Bile Duct Disease and Biliary Tract Disease. Among its related pathways are Farnesoid X Receptor Pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is PTGIS.

Full Name

Cytochrome P450 Family 8 Subfamily B Member 1

Function

A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:10051404).

Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity).

Biological Process

Bile acid biosynthetic process Source: UniProtKB
Bile acid signaling pathway Source: Ensembl
Positive regulation of intestinal cholesterol absorption Source: UniProtKB
Response to cholesterol Source: Ensembl
Response to nutrient levels Source: Ensembl
Sterol metabolic process Source: Reactome

Cellular Location

Endoplasmic reticulum membrane; Microsome membrane

Topology

Helical: 1-21