DDAH2

This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq]

Full Name

dimethylarginine dimethylaminohydrolase 2

Function

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Biological Process

Arginine catabolic process Source: ProtInc
Arginine metabolic process Source: GO_Central
Citrulline metabolic process Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Nitric oxide biosynthetic process Source: ProtInc
Nitric oxide mediated signal transduction Source: ProtInc
Positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
Regulation of nitric-oxide synthase activity Source: Reactome

Cellular Location

Cytoplasm; Mitochondrion. Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.