DDC

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
Full Name
Dopa Decarboxylase
Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Biological Process
Aminergic neurotransmitter loading into synaptic vesicle Source: Ensembl
Catecholamine biosynthetic process Source: Reactome
Catecholamine metabolic process Source: GO_Central
Cellular amino acid metabolic process Source: InterPro
Cellular response to alkaloid Source: Ensembl
Cellular response to drug Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Circadian rhythm Source: Ensembl
Dopamine biosynthetic process Source: UniProtKB-UniPathway
Indolalkylamine biosynthetic process Source: Reactome
Isoquinoline alkaloid metabolic process Source: Ensembl
Multicellular organism aging Source: Ensembl
Phytoalexin metabolic process Source: Ensembl
Response to pyrethroid Source: Ensembl
Serotonin biosynthetic process Source: GO_Central
Cellular Location
Cytosol; Extracellular exosome; Axon; Cytoplasm; Neuronal cell body; Synaptic vesicle
Involvement in disease
Aromatic L-amino-acid decarboxylase deficiency (AADCD):
An inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
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Anti-DDC antibodies

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Mouse Anti-DDC Recombinant Antibody (8E8) (CBMAB-0992-YC)

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Target: DDC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 8E8
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-DDC Recombinant Antibody (CBYC-A948) (CBMAB-A4376-YC)

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Target: DDC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse, Rat
Clone: CBYC-A948
Application*: WB, IP, IF, IH
Datasheet SDS

Rabbit Anti-DDC Recombinant Antibody (5) (CBMAB-D0477-YC)

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Target: DDC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 5
Application*: E
Datasheet SDS

Rabbit Anti-DDC Recombinant Antibody (D0474) (CBMAB-D0474-YC)

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Target: DDC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D0474
Application*: E, P
Datasheet SDS

Mouse Anti-DDC Recombinant Antibody (CL2962) (CBMAB-1039-YC)

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Target: DDC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CL2962
Application*: E
Datasheet SDS

Mouse Anti-DDC Recombinant Antibody (CBYCD-203) (V2LY-0125-LY1296)

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Target: DDC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYCD-203
Application*: WB
Datasheet SDS

Rabbit Anti-DDC Recombinant Antibody (1040) (V2LY-0125-LY1295)

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Target: DDC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1040
Application*: E
Datasheet SDS

DDC Matched Antibody Pair (330) (APMAB-330LY)

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Target: DDC
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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